Understanding Adrenal Hormones The adrenals make 2 important hormones, cortisol (a glucocorticoid) and aldosterone (a mineralocorticoid). Patients with adrenal insufficiency from an adrenal cause such as an adrenalectomy or Addison disease require replacement of both hormones, Although the natural mineralocorticoid is aldosterone, we give fludrocortisone or Florinef as a replacement. The glucocorticoid and mineralocorticoid axis […]