Understanding Glucocorticoid Replacement for Adrenal Insufficiency Patients with adrenal insufficiency, either due to a pituitary problem or an adrenal problem, need glucocorticoid replacement. Patients with adrenal causes of adrenal insufficiency, such as those who have had an bilateral adrenalectomy for Cushing’s disease, need both glucocorticoid and mineralocorticoid replacement. Glucocorticoid replacement is usually given in the […]