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CURRICULUM VITAE

Click on the outline below for details of Dr. Friedman's professional history.

EDUCATION
   Degrees
   PhD Thesis
   Traineeships 
   Honors
PROFESSIONAL EXPERIENCE
   Positions Held
   Committee Service
   Memberships
   Editorial Activities
   Grant Reviewer
   Awards and Recognition
   Licensure and Board Certification
RESEARCH GRANTS
   Research Grants Submitted
LECTURES & PRESENTATIONS
   Media Appearances
PUBLICATIONS & BIBLIOGRAPHY
   Research Papers
   Chapters in Books
   Letters to the Editor
   Reviews
   Abstracts

EDUCATION

DEGREES

B.S., Chemistry and Biological Sciences, Stanford
  University, Stanford, Ca. 1980
M.Phil., Pharmacology, City University of New York,   N.Y., N.Y.  1984
Ph.D., Pharmacology, City University of New York, N.Y.,   N.Y.  1986
M.D., M.D.-Ph.D. program, Mount Sinai School of   Medicine, N.Y.  1987

Ph.D. THESIS

Studies on the Effects of Inhibitors of TR4-degrading Enzymes 1982-1985.  Preceptor: Sherwin Wilk, Ph.D. Department of Pharmacology, Mount Sinai School of Medicine

TRAINEESHIPS

RESIDENCY at University of Michigan Hospitals, 1987-1989 Internal Medicine Ann Arbor, MI.

FELLOWSHIP at National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD. 1989-1992 Endocrinology

SENIOR STAFF FELLOW at National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD. 1992-1995 Endocrinology

HONORS

Graduated with Distinction from Stanford University 1980

Doctoral Dissertation Award for best thesis, Mount Sinai School of Medicine 1986
NIH Student Exchange Program-Elective in Endocrinology 1986
Hadassah Hospital Student Exchange Program, Jerusalem, Israel  1987

PROFESSIONAL EXPERIENCE

POSITIONS HELD

UCLA School of Medicine 2005-
Chief, Division of Endocrinology, Metabolism and Molecular Medicine,Charles R. Drew University of Medicine and Science.
UCLA School of Medicine 2000-
Associate Professor of Medicine-In-Residence Level 3 Endocrinology Division Charles R. Drew University of Medicine & Science Los Angeles, CA
Martin Luther King Medical Center 2000-
Director, Endocrinology Fellowship Program
Charles R. Drew University of Medicine & Science 2000-
Director, Body Composition Core of the Drew Center of Excellence for Metabolic Research
UCLA School of Medicine 1995-2000
Associate Professor of Medicine-Level 4 Endocrinology Division, Cedars-Sinai Medical Center Los Angeles, CA
Cedars-Sinai Medical Center 1998-2000
Director, Multi-Disciplinary Chronic Fatigue Clinic

COMMITTEE SERVICE

Cedars-Sinai Medical Center Education Committee 9/96-2000
Cedars-Sinai Medical Center Medical Informatics QAT 9/97-2000
Charles R. Drew University Animal Care Committee 2000-

MEMBERSHIPS

Endocrine Society 1990-
Los Angeles Cross Town Endocrine Club 1995-
American Diabetes Association 1996-
AACFS 2002-
Los Angeles Reproductive Endicrinology Club
(founder and president) 2002-

EDITORIAL ACTIVITIES

Ad-hoc reviewer for:
   Endocrinology 1/95-
   Journal of Clinical Endocrinology and    Metabolism1/95-
   Peptides 1/95-
   Pharmacology Biochemistry and Behavoir 6/97-
  Journal of Clinical Investigation 7/00-
  Journal of Molecular Endocrinology 12/01-
  Diabetes Care 1/03-

GRANT REVIEWER

Ad-hoc reviewer for Canadian Diabetes Association 2000
Ad-hoc reviewer for IFCN-2 Study section 2000
Reviewer for Special Study Section on Gene Therapy and Diabetes 2001
Ad-hoc reviewer for the Hospital for Sick Children Foundation 2001
Mail reviewer for CEBRA (Cutting Edge Basic Research Awards- NIDA 2003

AWARDS AND RECOGNITION

"Endocrinology Under 35" Meeting, Best Poster Award,Rapallo Italy 1992
Outstanding Achievements in Promoting Black Employees Award 1993
Charles E. Culpeper Foundation Research Fellow 1996-1998
Mentor Drew Magnet High School Program 2000-
Mentor of Melo Yap, 3rd place winner of the Biochemistry category, LA County Science Fair for high school students. 2001

LICENSURE & BOARD CERTIFICATION

California State License #G81765 1995-
DEA # BF4533495
Board Certified, Internal Medicine 1990
Board Certified, Endocrinology, Diabetes and Metabolism 1993

RESEARCH GRANTS

RESEARCH GRANTS RECEIVED

NIH S06GM068510-01 Minority Biomedical Research Support . Program Director-Friedman
MBRS Score Program at Charles R. Drew University of Medicine & Science. 8/1/03-7/31/07. Direct costs $2,046,034/Total costs $2,906,743.

NIH R24DA017298-01-A1 Program Director-Friedman
MIDARP Program at Charles R. Drew University of Medicine & Science. 12/1/03-11/30/08. Direct costs $1,750,000/Total costs $2,502,500.

NIH 1U54 HD41748-01 PI -Friedman
Physiologic testerone Replacement in Women with Hypopituitarism. (part of reproductive Center of Excellence entitled "Biologic Effects of Androgens in Men and Women") 3/1/03-2/29/08. Direct costs $1,250,000/ Total costs $1,768,750.

CFIDS Association of America Research Grant, PI-Friedman. Decreased Cerebral Blood Flow and Orthostasis in CFS. 2/1/03-1/31/04. Direct costs $72,727/Total costs $80,000.

NIH R01DA14659-01A1, PI-Friedman
Genes and Proteins Leading to Addiction.
8/1/02-7/30/07. Direct costs $750,000, Total costs $1,068,750.

NIH R21DA15466-01-A1 PI-Friedman
HPA axis activation and nicotine use.
4/1/03-3/31/06. Direct costs $3000,000/Total costs $427,500.

NIH-R21DA016867-01-A1 PI-Friedman
Chronic Nicotine's Activation of the HPA Axis
7/1/03-6/30/06. Direct costs $300,000/Total costs $427,500.

NIH-Construction Grant, Co-applicant (PI:Francis/Norris)
Exrtamural Research Facilities Construction (clinical research). 9/1/02. Direct costs $3,000,000/Total costs $3,000,000.

NIH-Construction Grant, Co-applicant (PI: Francis/Norris)
Extramural Research Facilities Construction (basic research) 2/1/03. Direct Costs $4,000,000/Total costs $4,000,000.

NIH- Animal Care Facility Grant, Co-applicant (PI-Norris)
Animal Care Facility/Transgenic-Phenotyping Mouse Program Enhancement-Supplement to RCMI Biomedical Research Center G12-RR03026-15
9/1/02-8/31/03. Direct costs $200,000/Total costs $200,000.

Pfizer Grant on uses of Viagra, PI-Friedman
Use of Sildenafil (Viagra®) to Improve Fatigue, Functional Status and Impaired Cerebral Blood Flow in Patients with Chronic Fatigue Syndrome
5/1/02-12/31/03. Direct costs $50,000/Total costs $435,000.

NIH-P20 RR11145-01 (Center of Excellence Grant), Co- investigator (PI-Francis/Norris). Regulation of Prohormone Convertases. 5/1/00-4/30/04. Direct costs $300,000/Total costs $435,000.

NIOSH-1R01OH007575-01, Co-Investigater (PI: Robbins)
Male Reproductive Effects from Exposure to Boron
9/30/01-9/29/06, Direct costs $380,790/year.

Thyroid Research Advisory Council (TRAC) Research Grant, PI
Regulation of PC1 and PC2 by Thyroid Hormone 7/1/00-6/30/02 Direct Costs $86,956/Total Costs $100,000

NIDA K21 DA00276-01, PI-Friedman
Structural Determinants in Regulation of POMC Processing 7/1/95- 6/30/01  Direct Costs-$667,628/Total Costs $721,038

Columbia Research Laboratories Clinical Study, Co-Investigator
Phase III study of Buccal Testosterone COL-1621 1/1/01-12/30/01 Direct Costs $61,200/Total Costs $76,250

Columbia Research Laboratories Clinical Study, Co-Investigator
An Open-label, Phase III, Multicenter Study of COL-1621, a Bioadhesive Buccal (in the mouth) Testosterone Tablet, for the Long-term Safety, Tolerability and Efficacy in Testerone Deficient Patients. 6/1/01-12/30/02. Direct costs $36,000/Total costs $45,000.

Charles E. Culpeper Foundation Research Award, PI-Friedman.
Structural Determinants in Regulation of Pro-opiomelanocortin Processing:Implications for Developing Novel Treatments for Drug Addiction 7/1/96- 6/30/98  Direct Costs-$200,000/Total Costs $200,000

ADA Research Grant, PI-friedman
Disordered IGF-I Biosynthesis: Implications in the Pathogenesis of Diabetic Complications 1/1/96- 12/31/97 Direct Costs-$100,000/Total Costs $100,000

RESEARCH GRANTS SUBMITTED

NIH RO1,1 RO1 DA015769-01-A2, PI ( to be resubmitted 11/03) Regulation of PC1/PC2 by Opiates 11/1/02-10/31/05
Direct costs $525,000/Total Costs 748,125

NIH RO1,PI , Renin-Aldosterone axis in CFS (recieved a score of 260, will be resubmitted) 2/1/03-1/31/06. Direct Costs $525,000/Total Costs $748,125

LECTURES AND PRESENTATIONS, (SELECTED)

  1.  University of Michigan Medical Center-Endocrine Research Conference-March 10, 1994.  In Vitro Processing of Pro-opiomelanocortin and Anthrax Toxin Protective Antigen by Recombinant PC1
  2. NIH Inter-institute Endocrine Grand Rounds-April 8, 1994.  In Vitro Processing of Pro-opiomelanocortin and Anthrax Toxin Protective Antigen by Recombinant PC1: Implications for Endocrine Tumor Targeting
  3. Eli Lilly Endocrine Noon Conference-April20, 1994.  In Vitro Processing of Pro-opiomelanocortin and Anthrax Toxin Protective Antigen by Recombinant PC1
  4. University of Colorado Medical Center- Clinical Pharmacology Seminar-July 21, 1994.  In Vitro Processing of Pro-opiomelanocortin and Anthrax Toxin Protective Antigen by Recombinant PC1: Implications for Endocrine Tumor Targeting
  5. National Heart Lung and Blood Institute Seminar-August 17, 1994.  Processing of Pro-opiomelanocortin by PC1 and PC2: Implications for Processing Vasoactive Peptide Precursors
  6. Cedars-Sinai Medical Center Special Research Seminar-December 1, 1994.  Processing of Pro-opiomelanocortin by PC1 and PC2: Insights from In Vitro and Antisense Experiments
  7. Cedars-Sinai Medical Center EndocrinologyResearch Seminar-May 19, 1995.  The Endocrinology of Sleep
  8. Institute de Biotechnologia/UNAM Seminar-Cuernavaca, Mexico- February 6, 1996.  Biosynthesis and Processing of TRH
  9. Cedars-Sinai Medical Center EndocrinologyResearch Seminar- February 9, 1996.  Biosynthesis and Processing ofTRH
  10. Harbor-UCLA Medical Center Clinical Endocrinology Conference- March 13, 1996.  Cushing Syndrome Versus Pseudo-CushingState- What to do?
  11. Cedars-Sinai Medical Center Endocrine Grand Rounds-April 16, 1996.  Cushing Syndrome Versus Pseudo-Cushing State-What to do?
  12. Hammersmith Hospital-Endocrinology Research Seminar-London, England-August 5, 1996.  Prohormone Processing
  13. University of Reading-Biochemistry and Physiology of Disease Research Group-Reading, England-August 8, 1996.  POMC and ProTRH Processing
  14. University of Bristol Medical Center-Department of Medicine Seminar-Bristol, England-August 12, 1996.  The Endocrinology of Sleep
  15. Royal Free Hospital-Endocrinology Research Seminar-London, England-August 13, 1996.  Pro-Hormone Convertases
  16. Cedars-Sinai Medical Center Endocrinology Research Seminar- September 27, 1996.  Pro-hormone Processing:Advances in Basic Science and Clinical Studies
  17.  University of Southern California Medical Center Endocrinology, Diabetes and Hypertension Grand Rounds-October 1, 1996.  Pro- hormone Processing:Advances in Basic Science and Clinical Studies
  18. City of Hope National Medical Center Diabetes, Endocrinology and Metabolism Clinical Conference-October 2, 1996.  Cushings Vs. PseudoCushings-How to Differentiate?
  19. Wadsworth VA Medical Center Endocrine Research Seminar-October 24, 1996.  Prohormone Processing:Advances in Basic Science and Clinical Studies
  20. Cedars-Sinai Medical Center Endocrinology Journal Club-December 13, 1996.  Two-Hybrid System
  21. UCLA Interdisciplinary Pituitary Conference-January 16, 1997.  Discussant on Recurrent or Persistent Cushing's Syndromein a 21 year old Woman
  22. Mount Sinai School of Medicine Endocrinology Grand Rounds-February 18, 1997.  Prohormone Processing:Advances in Health and Disease
  23. The New York Hospital-Cornell Medical Center Division of Endocrinology, Diabetes and Metabolism Weekly Conference-February 19, 1997.  Prohormone Processing:Advances in Basic Science and Clinical Studies
  24. Cedars-Sinai Medical Center Endocrine Grand Rounds-March 4, 1997.  Processing Enzymes in Health and Disease
  25. Cedars-Sinai Medical Center Medical Genetics Seminar-March 13, 1997.  Prohormone Processing:Advances in Basic Science and Clinical Studies
  26. Cedars-Sinai Medical Center Endocrine Grand Rounds-March 25, 1997.  The Endocrinology of Sleep
  27. Cedars-Sinai Medical Center Endocrinology Research Seminar- October 31, 1997.  Genes Involved in Spermatogenesis
  28. UCLA Interdisciplinary Pituitary Conference-November 20, 1997.  Growth Hormone Deficiency
  29. Cedars-Sinai Medical Center Endocrine Grand Rounds-January 13, 1998.  The Endocrinology of Fatigue
  30.  UCLA Interdisciplinary Pituitary Conference-May 28, 1998.  Problems in the Diagnosis of Cushing's Syndrome
  31. Charles R. Drew Endocrine Clinical Conference-June 10, 1998.  Endocrinology of Fatigue
  32. Endocrine Society "Meet the Professor"-June 24, 1998.  Cushing's Syndrome
  33. Cedars-Sinai Medical Center Endocrine Grand Rounds-September 15, 1998.  Cushings vs Pseudocushings
  34. California Pituitary Conference -October23, 1998.  Cushing's Disease
  35. Cedars-Sinai Medical Center Endocrinology Research Seminar- November 6, 1998.  Regulation of the Prohormone Convertases:A Novel Mechanism to Maintain Hormonal Homeostasis
  36. Cedars-Sinai Medical Center Endocrine Grand Rounds-February 23, 1999.  The Endocrinology of Chronic Fatigue
  37. Cedars-Sinai Medical Center Endocrine Grand Rounds-May 11, 1999.  Prohormone Processing
  38. UCLA Interdisciplinary Pituitary Conference-September 30, 1999.  Repeat Surgery, Radiation or Adrenalectomy in Recurrent Cushing's Syndrome
  39. Cedars-Sinai Medical Center Endocrine Grand Rounds-October 5, 1999.  Update on Cushing's Syndrome
  40. California State University-LA Biology and Microbiology Seminar- November 2, 1999.  Regulation of the Prohormone Convertases: A Novel Mechanism to Maintain Hormonal Homeostasis
  41. Charles R. Drew Endocrine Clinical Conference-January 6, 2000.  Regulation of the prohormone convertases: A novel mechanism to maintain hormonal homeostasis in Diabetes
  42. University of Southern California Medical Center Division of Endocrinology and Diabetes Grand Rounds-February 1, 2000.  Regulation of the prohormone convertases: A novel mechanism to maintain hormonal homeostasis in Diabetes
  43. Harbor-UCLA Medical Center Clinical Endocrinology Conference- February 23, 2000.  Regulation of the prohormone convertases: A novel mechanism to maintain hormonal homeostasis in Diabetes
  44. Cedars-Sinai Medical Center Endocrinology Research Seminar- February 25, 2000.  Regulation of the prohormone convertases: A novel mechanism to maintain hormonal homeostasis in Diabetes
  45. Wadsworth VA Medical Center Endocrine Research Seminar-June 9, 2000.  Endocrinology of Chronic Fatigue.
  46. MLK/Drew Pathophysiology Lecture Series-June 19, 2000.  The Adrenal Gland.
  47. Charles R. Drew Endocrine Clinical Conference-June 28, 2000.  Endocrinology of Chronic Fatigue.
  48. Charles R. Drew Emergency Medicine Conference-September 11, 2000, Adrenal Insufficiency.
  49. City of Hope Endocrine Clinical Conference- September 13, 2000, Endocrinology of Chronic Fatigue.
  50. Charles R. Drew Endocrine Clinical Conference-February 21, 2001, Diagnosis of Difficult Cases of Cushing's Syndrome.
  51. Providence Holy Cross Medical Center Clinical Conference-March 27, 2001, The Practical Evaluation and Management of Adrenal Insufficiency for the Hospitalist and the Primary Care Physician.
  52. Charles R. Drew Endocrine Basic Conference-July 23,2001, Hormones Involved in Obesity/Role of 7B2.
  53.  National Youth Leadership Forum on Medicine-July 25, 2001, Careers in Academic Medicine.
  54. Charles R. Drew Internal Medicine Grand Rounds-September 12, 2001, Adrenal Insufficiency.
  55. Cedars-Sinai Medical Center Endocrinology Research Seminar-November 27, 2001, Endocrinology of Chronic Fatigue.
  56. Charles R. Drew Endocrine Clinical Conference-February 20, 2002 How to Diagnosis Early Cushing's.
  57. City of Hope Endocrine Clinical Conference- June 5, 2002 Adrenal Insufficiency.
  58. Pituitary Patient Congress (sponsored by the Pituitary Network Association) June 27, 2002 The Logical Progression: Building your own best team for rest of life care.
  59. Pituitary Patient Congress (sponsored by the Pituitary Network Association) June 28, 2002 Cushing's Syndrome (session chair and keynote speaker).
  60. National Youth Leadership Forum on Medicine-July 10, 2002 Careers in Academic Medicine.
  61. Charles R. Drew Internal Medicine Grand Rounds-September 19, 2002 Endocrinology of Chronic Fatigue.
  62. King Drew Medical Center New Technologies in Medicine Conference-October 25, 2002 New Technologies in Endocrinology.
  63. Harbor-UCLA Medical Center Clinical Endocrinology Conference-November 5, 2002 Everything you Need to Know to Diagnose Cushing's Syndrome.
  64. Cedars-Sinai Medical Center Endocrinology Grand Rounds-March 4, 2003 Renin/Aldosterone Axis in Chronic Fatigue Syndrome.
  65.  West LA VA Medical Center Endocrine Research Seminar-March 14, 2003 Cushing's Syndrome.
  66. Women's Sexual Health State-of-the-Art Series (Santa Monica, CA)-March 16, 2003. Assays and Measurement Issues: Can Androgen Deficiency Be Reliably Addressed in Women?
  67. Harbor-UCLA Medical Center Internal Medicine Grand Rounds-April 1, 2003 Comprehensive Hormone Replacement in Patients with Hypopituitarism.
  68. UCLA Pituitary Patient Care Support-April 10, 2003 Hormone Replacement in Patients with Hypopituitarism-We Simply Need to Do More.
  69. Charles R. Drew Endocrine Clinical Conference-May 21, 2003 Nuances of Hormone Replacement for Hypopituitarism-part I.
  70. Charles R. Drew Endocrine Clinical Conference-June 4, 2003 Nuances of Hormone Replacement for Hypopituitarism-part II.
  71. New Jersey Medical School-War Related Illnesses Special Conference- June 25, 2003 Endocrine Causes of Chronic Fatigue.
  72. Charles R. Drew Endocrine Division of Research Grant Writing Series-July 21, 2003-Specific Aims and Hypothesis.
  73. Charles R. Drew Endocrine Division of Research  Grant Writing Series-July 28, 2003-Background   and Preliminary Data.
  74. Charles R. Drew Endocrine Division of Research Grant Writing Series-August 4, 2003-Methods.
  75. Charles R. Drew Endocrine Division of Research Grant Writing Series-August 18, 2003-Resubmissions.
  76. West LA VA Medical Center Endocrine Research Seminar-September 4, 2003 Nuances of Hormone Replacement for Hypopituitarism-part I.
  77. Cedars-Sinai Medical Center Endocrinology Grand Rounds-September 30, 2003 Nuances of Hormone Replacement for Hypopituitarism-part I
  78. Cedars-Sinai Medical 7Center Endocrinology Grand Rounds-October 14, 2003 Nuances of Hormone Replacement for Hypopituitarism-part II
  79. Providence Holy Cross Medical Center Clinical Conference-October 21, 2003 Diagnosis & Management Of Adrenal Insufficiency In Hospitalized Patients.

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MEDIA APPEARANCES

  1. Fitness Talk with Dr. Fitness (Lance Drayer)-KFYI Radio (Phoenix, AZ)- November 12, 2000 Insulin Resistance and Stress.
  2. Fitness Talk with Dr. Fitness (Lance Drayer)-KFYI Radio (Phoenix, AZ)- May13, 2001 Insulin Resistance and Diet for Women.
  3. Power Surge Internet Chat: Everything you need to know about hormone imbalances June 28, 2001
  4. CBS National News (The Early Show with Bryant Gumbel and Jane Clayson) (http://cbsnews.com/earlyshow/healthwatch/healthnews/20020227hw_cushings.shtml), February 27, 2002, Cushing's Disease
  5. KPHO TV Evening News (Phoenix, AZ) February 26, 2002 Cushing's Disease.
  6. Los Angeles Times op/ed article in the "Voices. A Forum for Community Issues" Section. A Guided Tour of King/Drew , (co-authors, S. Bhasin and M. Davidson) Sept. 20, 2003, p. B25.

PUBLICATIONS & BIBLIOGRAPHY

RESEARCH PAPERS

A. RESEARCH PAPERS (PEER-REVIEWED)

  1. Friedman, T. C., Orlowski, M. and Wilk, S. (1984) Prolyl Endopeptidase: Inhibition in vivo by N- benzyloxycarbonyl-prolyl-prolinal. J. Neurochem.  42: 237-241.
  2. Friedman, T. C., Orlowski, M. and Wilk, S. (1984) Peptide-Degrading Enzymatic Activities in GH3 Cells and Rat Anterior Pituitary Homogenates.  Endocrinology 114: 1407-1412
  3. Friedman, T. C., Kline, T. B. and Wilk, S. (1985) 5-Oxoprolinal: Transition State Aldehyde Inhibition of Pyroglutamyl Peptide Hydrolase. Biochemistry 24: 3907-3913.
  4. Wilk, S., Friedman, T. C. and Kline, T. B. (1985)  Pyroglutamyl Diazomethyl Ketone: Potent Inhibitor of Mammalian Pyroglutamyl Peptide Hydrolase.   Biochem. Biophys. Res. Commun. 130: 662-668.
  5. Friedman, T. C. and Wilk, S. (1985) The Effects of  Inhibitors of Prolyl Endopeptidase and Pyroglutamyl  Peptide Hydrolaseon TRH Degradation in Rat Serum. Biochem. Biophys. Res. Commun. 132:   787-794.
  6. Friedman, T. C., Davies, T. F. and Wilk, S. (1986) Evidence for Regulation of a TRH Degradation   Pathway in GH3 Cells.  Endocrinology 118:    562-  566.
  7. Friedman, T. C., and Wilk, S. (1986) Delineation of a Particulate Thyrotropin-Releasing  Hormone- Degrading Enzyme in Rat Brain by the Use of Specific Inhibitors of Prolyl Endopeptidase and Pyroglutamyl Peptide Hydrolase. J.  Neurochem.  46: 1231-1239.
  8.  Friedman, T. C. and Fulop, G. (1988) Disulfiram Use at Hospital-Based and Free-Standing Alcoholism Treatment Centers. J.Subst. Abuse Treatment 5:139-143.
  9. Friedman, T.C., Thomas, P.M., Fleisher, T.A., Feuillan, P., Parker, R. I., Cassorla, F. and  Chrousos, G.P. (1991) Frequent Occurence of  Asplenism and Gallstones in Patients with Autoimmune Polyglandular Disease Type I. Am. J.  Med. 91:625-631.
  10. Estivariz, F.E., Friedman, T.C., Chikuma, T. and Loh, Y.P. (1992) Processing of Adrenocorticotropin by Two Proteases in Bovine  Intermediate Lobe Secretory Vesicle Membranes: A Distinct, Acidic, Tetrabasic-Residue Specific,   Calcium-Activated Serine Protease, and a  PC2- like Enzyme. J. Biol. Chem. 267:7456-7463.
  11. Doppman, J.L., Gill, J.R. Jr., Miller, D.L., Chang,  R., Gupta, R., Friedman, T.C., Choyke, P.L., Feurstein, I.M., Dwyer, A.J., Jicha, D.L., Walther, M.M., Norton, J.A. and Linehan, W.M. (1992)  Distinction Between Hyperaldosteronism Due to  Bilateral Hyperplasia and Unilateral   Aldosteronoma: Reliability of CT.  Radiology  184:677-682. 
  12.  Oerter, K.E., Friedman, T.C., Andersson H.C. and  Cassorla, F.G. (1992) A Familial  Syndrome of  Endocrine and . 44:487-491.
  13.  Mixson, A.J., Friedman, T.C., Katz, D.A., Feuerstein, I.M., Taubenberger, J.K.,  Colandrea  J.M., Oldfield, E.H andWeintraub, B.D. (1993) Thyrotropin- Secreting Pituitary Carcinoma. J.   Clin.Endocrinol. Metab. 76:529-533. 
  14. Azaryan, A.V., Wong, M., Friedman, T.C.,Cawley,  N.X., Estivariz, F.E., Chen,    H.-C., and Loh, Y.P.  (1993) PurificationandCharacterization of a Novel Yeast Aspartic Protease Encoded by the YAP3Gene:Similarity tothe Mammalian Proopiomelanocortin Converting Enzyme.J. Biol.Chem. 260:7194-7205.
  15. Crofford, L.J., Sano, H., Karalis, K., Friedman, T.C., Epps, H.R., Remmers, E.F., Mathem, P., Chrousos, G.P., and Wilder,R.L. (1993) Corticotropin-Releasing Hormone in Synovial Fluids and Tissuesof Patients with Rheumatoid Arthritis and Osteoarthritis. J. Immunol. 151:1587-1596.
  16. Mastorakos, G., Webster, E.L., Friedman,T.C., and Chrousos, G.P. (1993) Immunoreactive Corticotropin Releasing Hormone(CRH) and its Binding Sites in the Rat Ovary.  J. Clin. Invest. 92:961-968.
  17. Bouzas, E.A., Mastorakos, G., Friedman, T.C., Scott, M.H., Chrousos, G.P., and Kaiser-Kupfer, M.I. (1993) Posterior Subscapsular Cataracts in Endogenous Cushing Syndrome: An Uncommon Manifestation. Invest. Ophthalmol. Vis. Sci. 34:3497-3500.
  18. Friedman, T.C., Chen, H.C., and Loh, Y.P. (1993) Generation of (1-37) and (1-38) Forms of Adrenocorticotropin By Mono- and Di-Peptidyl Serine Carboxypeptidase Activities in Bovine Pituitary Secretory Vesicles. Endocrinology 133:2951-2961.
  19. Auchus, R.J., Mastorakos, G., Friedman, T.C., and Chrousos, G.P. (1994) Corticotropin-Releasing Hormone Production by a Small Cell Lung Carcinoma in a Patient with ACTH-Dependent Cushing Syndrome. J. Endocrinol. Invest. 17:447-452.
  20. Friedman, T.C., Garcia-Borreguero, D., Hardwick, D., Akuete, C.N., Stambuk, M.K., Dorn, L.D., Starkman, M.N., Loh, Y.P., and Chrousos, G.P. (1994) Diurnal Rhythm of Plasma Delta Sleep-Inducing Peptide in Humans: Evidence for Positive Correlation with Body Temperature and Negative Correlation with Rapid Eye Movement and Slow Wave Sleep. J. Clin. Endocrinol. Metab. 78:1085-1089.
  21. Mastorakos, G., Scopa, C.D., Vryonidou, A., Friedman, T.C., Kattis, D., Phenekos, C., Merino, M.J., and Chrousos, G.P. (1994) Presence of Immunoreactive Corticotropin Releasing Hormone (CRH) in Normal and Polycystic Human Ovaries. J.Clin. Endocrinol. Metab. 79:1191-1197.
  22. Friedman, T.C., Loh, Y.P and Birch, N.P.(1994) In Vitro Processing of Pro-opiomelanocortin by Purified RecombinantPC1(SPC3). Endocrinology 135:854-862.
  23. Friedman, T.C., Garcia-Borreguero, D., Hardwick, D., Akuete, C.N., Doppman, J.L., Dorn, L.D., Yanovski, J.A., and Chrousos, G.P. (1994) Decreased Delta Sleep and Plasma Delta Sleep-Inducing Peptide Concentrations in Patients with Cushing Syndrome Neuroendocrinol. 60:626-634.
  24. Scopa, C.D., Mastorakos, G., Friedman, T.C., Melanchrinou, M., Merino, M.J., and Chrousos, G.P. (1994) Presence of Immunoreactive Corticotropin Releasing Hormone in Thyroid Lesions. Am. J. Pathol. 145:1159-1167.
  25. Pu, L-P., Hayes, W.P., Mill, J.F., Friedman, T.C., and Loh, Y.P. (1995) Expression of the Prohormone Convertase PC2 mRNA in Xenopus Laevis CNS: Co-localization with Pro-Thyrotropin-Releasing Hormone. J. Comp. Neuro. 354:71-86.
  26. Friedman, T.C., Gordon, V.M., Leppla, S.H., Klimpel, K.R., Birch, N.P. and Loh, Y.P. (1995) In Vitro Processing of Protective Antigen by Recombinant PC1(SPC3) and Bovine Intermediate Lobe Secretory Vesicle Membranes. Arch. Biochem. Biophys. 316:5-13.
  27. Friedman, T.C., Yanovski, J.A., Jayasvasti, V., Yanovski, S.Z., Koenig, R.J., and Wilk, S. (1995) Pyroglutamyl peptidase II ("Thyroliberinase") Activity in Human Serum: Influence of Weight and Thyroid Status. J. Clin. Endocrinol. Metab. 80:1086-1089.
  28. Friedman, T.C., Loh, Y.P., Cawley, N.X.,Birch, N.P., Huang, S.S., Jackson, I.M.D., and Nillni, E.A. (1995) ProcessingofPro-TRH by Bovine Intermediate Lobe Secretory Vesicle Membrane PC1 andPC2Enzymes. Endocrinology 136:4462-4472.
  29. Mastorakos, G., Bouzas, E.A., Silver, P.B., Friedman, T.C., Chan, C-C., Caspi, R.R., and Chrousos, G.P. (1995) Immune Corticotropin-Releasing Hormone is Present in the Eyes of and Promotes Experimental Autoimmune Uveoretinitis in Rodents. Endocrinology 136:4650-4658.
  30. Vgontzas, A.N., Friedman, T.C., Chrousos, G.P., Bixler, E.O., Vela-Bueno, A., and Kales, A. (1995) Delta Sleep-Inducing Peptide in Normals and in Sleep Apnea and Narcolepsy. Peptides 16:1153-1156.
  31. Dorn, L.D., Burgess, E.S., Dubbert, B., Simpson, S.-E., Friedman, T., Kling, M., Gold, P.W., and Chrousos, G.P. (1995) Psychopathology in Patients with Cushing Syndrome: Melancholic or "Atypical" Features. Clin. Endocrinol. 43:433-442.
  32. Nillni, E.A., Friedman, T.C., Todd, R.B., Birch, N.P. Loh, Y.P., and Jackson, I.M.D. (1995) ProTRH Processing by PC1. J. Neurochem. 65:2462-2472.
  33. Friedman, T.C. and Yanovski, J.A. (1995)Morning Plasma Free Cortisol: Inability to Distinguish Patients with MildCushingSyndrome from Patients with Pseudo-Cushing States. J. Endocrinol.Invest.18:696-701.
  34. Friedman, T.C., Cool, D.R., Jayasvasti, V., Louie, D., and Loh. Y.P. (1996) Processing of Pro-opiomelanocortin in GH3 Cells: Inhibition by Prohormone Convertase 2 (PC2) Antisense mRNA. Mol. Cell. Endocrinol. 116:89-96.
  35. Mastorakos, G., Scopa, C.D., Kao, L.C., Vryonidou, A., Friedman, T.C., Kattis, D., Phenekos, C., Rabin, D., and Chrousos, G.P. (1996) Presence of Immunoreactive Corticotropin Releasing Hormone Human Endometrium. J. Clin. Endocrinol. Metab. 81:1046-1050.
  36. Kalogeras, K.T., Nieman, L.K., Friedman,T.C., Doppman, J.L., Cutler, Jr., G.B., Chrousos, G.P., Wilder, R.L., Gold,P.W., and Yanovski, J.A. (1996) Inferior Petrosal Sinus Sampling in HealthyHuman Subjects Reveals a Unilateral Corticotropin-releasing Hormone-inducedArginine Vasopressin Release Associated with Ipsilaterally Lateralized Adrenocorticotropin Secretion. J. Clin. Invest. 97:2045-2050.
  37. Friedman, T.C., Yanovski, J.A., Nieman, L.K., Doppman, J.L., Cutler, Jr., G.B., Oldfield, E.H., Gold, P.M., Chrousos, G.P., and Kalogeras, K.T. (1996) Inferior Petrosal Sinus Arginine Vasopressin Concentrations in Normal Volunteers and Patients with Cushing's Disease. J. Clin. Endocrinol. Metab. 81:3068-3072.
  38. Yanovski, J.A., Yanovski, S.Z., Friedman, T.C., Loh, Y.P., Jayasvasti, V., Cutler, Jr., G.B., and Chrousos, G.P. (1996) Etiology of the Differences in Corticotropin-Releasing Hormone-Induced ACTH Secretion of Black and White Women. J. Clin. Endocrinol. Metab. 81:3307-3311.
  39. Friedman, T.C., Mastorakos, G., Bouzas, E.A., Newman, T.D., Mullen, N.M., Horton, E.G., Costello, R., Papadopoulos, N.M., and Chrousos, G.P. (1996) Carbohydrate and Lipid Metabolism in Endogenous Hypercortisolism:  Shared Features with Metabolic Syndrome X and NIDDM. Endocrine J. 43:645-655.
  40. Dorn, L.D., Burgess, E.S., Friedman, T.,Gold, P.W., and Chrousos, G.P. (1997) The Longitudinal Course of Psychopathology in Cushing's Syndrome after Correction of Hypercortisolism. J. Clin. Endocrinol. Metab. 82:912-919.
  41. Taymans, S.E., DeVries, A.C., DeVries, M.B., Nelson, R.J., Friedman, T.C., Castro, M., Detera-Wadleigh, S., Carter, C.S., and Chrousos, G.P. (1997) The Prairie Vole (Microtus Ochrogaster) as a Model of Glucocorticoid Resistance. Gen. Comp. Endocrinol. 106:48-61.
  42. Yanovski, J.A., Friedman, T.C., Nieman, L.K., Chrousos, G.P., Cutler, Jr., G.B., Doppman, J.L., and Kalogeras, K.T. (1997) Inferior Petrosal Sinus Arginine Vasopressin in Patients with Cushing Syndrome. Clin. Endocrinol. 47:199-206.
  43. Ting, P., Cushenberry, P.A., Friedman, T.C., and Loh, Y.P. (1997) Enhanced Brain Opioid Receptor Activity Precedes Blood-Brain Barrier Disruption. Acta Neurochir. (Suppl.) 70:250-253.
  44. Li, Q.-L., Yano, H., Ren, S.G., Li, X., Friedman, T.C., Melmed, S. (1997) Leukemia Inhibitory Factor (LIF) Modulates Pro-opiomelanocortin (POMC) Gene Regulation in Stably-Transfected AtT-20 Cells Over-Expressing LIF. Endocrine 7:325-330.
  45. Shimon, I., Yan, X., Magoffin, D.A., Friedman, T.C., and Melmed, S. (1998) Intact Leptin Receptor is Selectively Expressed in Human Fetal Pituitary and Pituitary Adenomas and Signals Human Fetal Pituitary Growth Hormone Secretion. J. Clin. Endocrinol. Metab. 83: 4059-4064.
  46. Yanovski, J.A., Miller, K.D., Kino, T., Friedman, T.C., Chrousos, G.P., Tsigos, C. and Falloon, J. (1999) Endocrine and Metabolic Evaluation of Human Immunodeficiency Virus-Infected Patients with Evidence of Protease Inhibitor-Associated Lipodystrophy. J. Clin. Endocrinol. Metab. 84:1925-1931.
  47. Li, Q.-L., Jansen, E., and Friedman, T.C. (1999) Regulation of Prohormone Convertase 1 (PC1) By gp130-Related Cytokines. Molecular and Cellular Endocrinology 158:143-152.
  48. Nie, Y., Nakashima, M., Brubaker, P.L., Li, Q.-L., Perfetti, R., Jansen, E., Zambre, Y., Pipeleers, D., and Friedman, T.C. (2000) Regulation of Pancreatic PC1 and PC2 Associated with Increased GLP-1 in Diabetic Rats. J. Clin. Invest. 105:955-965.
  49. Nawab, S.S., Miller, C.S., Dale, J.K., Greenberg, B.D., Friedman, T.C., Chrousos, G.P., Straus, S.E., and Rosenthal, N.E. (2000) Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls. Psychiatry Res. 95:67-74.
  50. Li, Q.-L., Jansen, E., Brent, G.A., Naqvi, S., Wilber, J.F., and Friedman, T.C. (2000) Interactions Between the Prohormone Convertase 2 (PC2) Promoter and the Thyroid Hormone Receptor. Endocrinology. 141:3256-3266.
  51. Garcia-Borreguero, D., Wehr, T.A., Larrosa, O., Granizo, J.J., Hardwick, D., Chrousos, G.P., and Friedman, T.C. (2000) Glucocorticoid Replacement is Permissive for REM sleep and Sleep Consolidation in Patients with Adrenal Insufficiency. J. Clin. Endocrinol. Metab. 85:4201-4206.
  52. Li, Q.-L., Jansen, E., Brent, G.A., and Friedman, T.C. (2001) Regulation of Prohormone Convertase 1 (PC1) by Thyroid Hormone. Am J. Physiol. 280:E160-E170.
  53. Nakashima, M., Nie, Y., Li, Q.-L, and Friedman, T.C. (2001) Induction of Splenic Prohormone Convertases PC1 and PC2 in Diabetic Rats. Reg. Peptides 102:135-45.
  54. Li, Q.-L., Naqvi, S., Shen, X., Liu, Y.-J., Lindberg, I., and Friedman, T.C. (2003) Prohormone Convertase 2 (PC2) Enzymatic Activity and its Regulation in Endocrine Cells. Reg. Peptides. 110:197-205.
  55. Liu, Y.J., Nakagawa, Y., Wang, Y., Li, R.S., Li. X.J. Ohzeki, T., and Friedman, T.C. (2003) Leptin Activates Intracellular Corticosterone Production in the Liver of ob/ob Mice. Diabetes. 52:1409-1416.

    B. RESEARCH PAPERS-PEER-REVIEWED(IN PRESS)

    C. RESEARCH PAPERS-PEER-REVIEWED (SUBMITTED):
       
       
  56. Wang, C., Swerdloff, R., Kipnes, M., Matsumoto, A. M., Dobs, A.S., Cunningham, G., Katznelson, L., Weber, T.J., Friedman, T.C., Snyder, P., Levine, H.L. (2004) New Testosterone Buccal System (Striant ) Delivers Physiologic Testosterone Levels: Pharmacokinetics Study in Hypogonadal Men. J. Clin. Endocrinol. Metab.
  57. Shen, X., Li, Q.-L., Brent, G.A., and Friedman, T.C. (2003) Thyroid Hormone Regulation of Prohormone Convertase 1 (PC1): Characterization of Negative Thyroid Hormone Response Elements and Studies in Rat Brain. Endocrinology.
  58. Nillni, E.A., Münzberg, H., Friedman, T.C. and Bjørbæk, C. (2003) Regulation of Hypothalamic Prohormone Convertase (PC1 and PC2) Expression by Leptin. Endocrinology.
  59. Nie, Y., Jansen, E., Li, Q.-L., and Friedman, T.C. (2003) Regulation of PC1 and PC2 by Morphine and Naltrexone: Implications for the Homeostatic Response to Opiate Addiction. Nature Medicine.
  60. Hardiman, A., Friedman, T.C., Grunwald, Jr., W. C., Furuta, M., Steiner, D.F., and Cool, D.R. (2003) Analysis of Posterior Pituitary Prohormone Processing in PC2-Null Mice Using SELDI-TOF Mass Spectrometry. J. Neurochem.
  61. Choi, J.-J. H., Cornford, M., Sun, J., Wang, L. and Friedman, T.C. (2003) A Mysterious Suprasellar Mass. Pituitary.
  62. Shen, X., Li, Q.-L., Brent, G.A., and Friedman, T.C. (2003) Regulation of Regional Expression in Rat Brain Prohormone Convertase 2 (PC2) by Thyroid Hormone/Characterization of Negative Thyroid Hormone Response Elements in the PC2 Promoter. Am. J. Physiol.

CHAPTERS

  1. Azaryan, A.V., Friedman, T.C., Cawley,N.X. and Loh, Y.P. (1995) Characteristics of YAP3, A New Prohormone Processing Aspartic Protease from S. Cerevisiae. in Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications (Takahashi, K., ed.) Plenum Press, New York, pp. 569-572.
  2. Loh, Y.P., Cawley, N.X., Friedman, T.C. and Pu, L-P. (1995) Yeast and Mammalian Paired Basic Residue-Specific Aspartic Proteases in Prohormone Conversion in Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications (Takahashi, K., ed.) Plenum Press, New York, pp. 519-527.
  3. Friedman, T.C. and Braunstein, G.D. (1997) Adrenal Gland in Cecil Essentials of Medicine, 4th edition (Andreoli, T.E., Bennett, J.C., Carpenter, C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, pp. 497-508.
  4. Herman-Bonert, V., Friedman, T.C. and Braunstein, G.D. (1997) The Thyroid Gland in Cecil Essentials of Medicine, 4th edition (Andreoli, T.E., Bennett, J.C., Carpenter, C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, pp. 487-496.
  5. Friedman, T.C. and Braunstein, G.D. (1999) Adrenal Gland in Cecil Essentials of Medicine, 5th edition (Andreoli, T.E., Bennett, J.C., Carpenter, C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, (in press).
  6. Herman-Bonert, V., Friedman, T.C. and Braunstein, G.D. (1999) The Thyroid Gland in Cecil Essentials of Medicine, 5th edition (Andreoli, T.E., Bennett, J.C., Carpenter, C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, (in press).
  7. Friedman, T.C. (2001) Pseudo-Cushing Syndrome in Contemporary Endocrinology: Adrenal Disorders (Margioris A.N. and Chrousos, G.P., eds.) Humana Press, Totowa, NJ, pp. 203-218.
  8. Friedman, T. (2001) Pseudo-Cushing's in Pituitary Patient Resources Guide, 3rd edition (Ezzat, S. and Knutzen, R. eds.) Pituitary Network Association, Thousand Oaks, CA, pp. 53-60.
  9. Friedman, T.C. (2004) The Adrenal Gland in Cecil Essentials of Medicine, 6th edition (Carpenter, C.C.J., Griggs, R.C. and Loscalzo, J., eds.) W.B. Saunders, Philadelphia, 603-614.
  10. Herman-Bonert, V. and Friedman, T.C. (2004) The Thyroid Gland in Cecil Essentials of Medicine, 6th edition (Carpenter, C.C.J., Griggs, R.C. and Loscalzo, J., eds.) W.B. Saunders, Philadelphia, 593-602.
  11. Friedman, T.C. and Cool, D.R. (2004) Prohormones in The Encyclopedia of Endocrinology and Endocrine Diseases, Martini, L. (ed.) Academic Press, San Diego, in press.

LETTERS TO THE EDITOR

  1.  Friedman, T.C., and Chrousos, G.P. (1993) Transsphenoidal Resection in Cushing's Disease: Definition of Success (letter). Clin. Endocrinol. 39:701.
  2. Friedman, T.C., and Papanicolaou, D. (1998) High Urinary Free Cortisol Excretion in a Patient with Psychogenic Polydipsia (letter). J. Clin. Endocrinol. Metab. 83:3378.
  3. Friedman, T.C., Adesanya, A. and Poland, R.E. (1999) Low-Dose Hydrocortisone Treatment Of Chronic Fatigue Syndrome: A Randomized Controlled Trial (letter). JAMA 281:1888.
  4. Friedman, T.C., Echeverry, D. and Poland, R.E. (2001) Orthostatic Hypotension and Chronic Fatigue Syndrome: A Randomized Controlled Trial (letter). JAMA 285:1442-1443.
  5. Padero, C., Friedman, T. Salehian, B. (2001) Comment on the Editorial "The role of Androgens in Women" (letter). J. Clin. Endocrinol. Metab. 86: 5091-2.

REVIEWS

REVIEWS-PEER-REVIEWED:
  1. Crofford, L.J., Sano, H., Karalis, K., Webster, E.A., Friedman, T.C., Chrousos, G.P., Wilder, R.L. (1995) Local Expression of Corticotropin-Releasing Hormone in Inflammatory Arthritis. Ann. N.Y. Acad. Sci. 771:459-471.
  2. Padero, C., Bhasin, S. Friedman, T.C. (2002) Androgen Supplementation in Older Women: Too Much Hype, Not Enough Data J. Am. Geriatr. Soc. 50:1131-1140.
  3. Friedman, T.C., Norris, K.C. (2002) The role of vitamin D hormone in mild to moderate chronic kidney disease. Trends Endocrinol Metab. 13:189-194.    

    REVIEWS-NON-PEER REVIEWED:
     
  4. Friedman, T.C., Pseudo Cushing's (1999) Network 8:16-18.
  5. Friedman, T.C. and Kimball, C. (2003) Endocrine Causes of Chronic Fatigue: A review of Symptoms, Treatments. The CFIDS Chronicle, 16:5-7.

ABSTRACTS

  1. Gal, J., Basile, A. and Friedman, T.C. (1979) In Vitro Reductive Metabolism of N-nitrosodibenzylamine. Pharmacologist 21: 191.
  2. Gal, J., Harper, T., Friedman, T.C. and Thompson, J.A. (1980) Stereoselective Reduction of Chiral Ketones to Chiral Alcohols by Rabbit Liver Cytosol. Pharmacologist 22: 242.
  3. Friedman, T. C., Orlowski, M. and Wilk, S. (1983) Inhibition of Prolyl Endopeptidase by Benzyloxycarbonyl-prolyl-prolinal In Vivo. Fed. Proc. 42: 357.
  4. Friedman, T.C., Davies, T. F. and Wilk, S. (1985) Inhibitor Stimulated Increase in Pyroglutamyl Peptide Hydrolase in GH3 Cells. Fifth Int. Washington Spring Symposium. Neural and Endocrine Peptides and Receptors.  Abst. #189.
  5. Wilk, S. and Friedman, T. C. (1985) Active-site Directed Inhibitors of TRH-Degrading Enzymes. Fifth Int. Washington Spring Symposium. Neural and Endocrine Peptides and Receptors. Abst. #142
  6. Wilk, S., Friedman, T. C. and Wilk, E. (1986) Purification and Properties of Rabbit Brain "Thyroliberinase", a Membrane-Bound Thyrotropin-Releasing Hormone Degrading Enzyme. Fed. Proc. 45: 796.
  7. Mixson, A., Friedman, T., Doppman, J., Oldfield, E. and Weintraub, B. (1990) Thyrotropin-Secreting Pituitary Carcinoma. Clinical Research 38:383A.
  8. Friedman, T. C. (1990) Concentrations of Delta Sleep-Inducing Peptide in Inferior Petrosal Sinus and Simultaneous Peripheral Venous Samples in Patients with Cushing's Syndrome. Endocrine Soc. 72:38.
  9. Friedman, T.C., Thomas, P. and Fleisher, T. (1991) High Prevalence of Asplenism and Gallstones in Patients with Autoimmune Polyglandular Disease Type I. Endocrine Soc. 73:98.
  10. Friedman, T.C., Kalogeras, K.T., Loh, Y.P., Doppman, J.L., Yanovski, J.A., Hardwick, D., Gold, P.W. and Chrousos, G.P. (1991) Concentrations of Arginine Vasopressin and Corticotropin-Releasing Hormone in Simultaneous Bilateral Inferior Petrosal Sinus and PeripheralVenous Samples in Patients with Cushing's Disease. First Summer NeuropeptideConference.
  11. Friedman, T.C., Thomas, P., Fleisher, T., Feuillan, P., Parker, R. I., Cassorla, F. and Chrousos, G.P. (1991) Occurence of Asplenism and Gallstones in Patients with Autoimmune Polyglandular Disease Type I. NIH Research Festival.
  12. Friedman, T.C., Kalogeras, K.T., Loh, Y.P., Doppman, J.L., Yanovski, J.A., Hardwick, D., Gold, P.W. and Chrousos, G.P. (1991) Concentrations of Arginine Vasopressin and Corticotropin-Releasing Hormone in Simultaneous Bilateral Inferior Petrosal Sinus and PeripheralVenous Samples in Patients with Cushing's Disease. NIH Research Festival.
  13. Friedman, T.C., Estivariz, F.E. and Loh,Y.P. (1991) Processing of Adrenocorticotropin by Two Proteases in BovineIntermediate Lobe Secretory Vesicle Membranes: An Acidic, Tetrabasic-ResidueSpecific,Calcium-Stimulated Serine Protease and a Kex2/PC2-like Protease.31th AnnualMeeting of the American Society for Cell Biology. Abst. #1749.
  14. Friedman, T.C., Hardwick, D., Garcia-Borreguero, D. and Loh, Y.P. (1992) Abnormal Thermoregulation in Patients with Cushing's Syndrome. Endocrine Soc. 74:855.
  15. Loh, Y.P., Friedman, T.C. and Estivariz,F.E. (1992) Identification and Partial Purification of Two Adrenocorticotropin-Processing Enzymes in Bovine Intermediate Lobe Secretory Vesicle Membranes. Endocrine Soc. 74:933.
  16. Loh, Y.P., Friedman, T.C., and Estivariz, F.E.. (1992) Characterization of Endoprotease and Carboxypeptidase ACTH-Processing Activities in Bovine Intermediate Lobe Secretory Vesicle Membranes. Second Summer Neuropeptide Conference.
  17. Friedman, T.C., Estivariz, F.E. and Loh,Y.P. (1992) Characterization of Endoprotease and Carboxypeptidase ACTH-Processing Activities in Bovine Intermediate Lobe Secretory Vesicle Membranes. Ninth International Congress of Endocrinology.
  18. Friedman, T.C., Hardwick, D., Garcia-Borreguero, D. and Loh, Y.P. (1992) Abnormal Thermoregulation in Patients with Cushing's Syndrome.  International Symposium on Endocrinology Under 35. Abst.#11.
  19. Friedman, T.C., Estivariz, F.E. and Loh,Y.P. (1992) Characterization of Endoprotease and Carboxypeptidase ACTH-Processing Activities in Bovine Intermediate Lobe Secretory Vesicle Membranes. NIH Research Festival.
  20. Mastorakos, G., Kokia, E., Webster, E.L., Friedman, T.C., Adashi, E.Y., and Chrousos, G.P. (1992) Ovarian Corticotropin-Releasing Hormone and its Potential Role. NIH Research Festival.
  21. Friedman, T.C., Chen, H.C., and Loh, Y.P. (1992) A Unique Serine Carboxyl-Terminal Adrenocorticotropin-Cleaving Enzyme in Bovine Intermediate Lobe Secretory Vesicle Membranes. 32nd Annual Meeting of the American Society for Cell Biology. Abst.#1122
  22. Friedman, T.C., Garcia-Borreguero, D., Hardwick, D., Akuete, C., Stambuk, M., Green, E., and Starkman, M.N. (1993) Circadian Rhythm of Plasma Delta Sleep-Inducing Peptide in Humans: Evidence for Correlation with Body Temperature But Not Sleep Stage. Endocrine Soc. 75:855.
  23. Nillni, E.A., Friedman, T.C., Todd, R.B., Birch, N.P., and Loh, Y.P. (1993) Enzymatic Conversion of ProTRH by Secretory Vesicle Membranes and Partially Purified PC1 Enzyme. Endocrine Soc. 75:1696.
  24. Azaryan, A.V., Wong, M., Friedman, T.C.,Cawley, N.X., Estivariz, F.E., Chen, H.-C. and Loh, Y.P. (1993) Characteristicsof YAP3, a New Prohormone Processing Aspartic Protease from S. Cerevisae.5th Aspartic Protease Conference.
  25. Friedman, T.C., Kalogeras, K.T., Loh, Y.P and Birch, N.P.. (1993) In Vitro Processing of POMC by Purified Recombinant PC1. 23rd Annual Meeting Society for Neuroscience. Abstract #441.6.
  26. Friedman, T.C., Loh, Y.P and Birch, N.P.(1993) In Vitro Processing of POMC by Purified Recombinant PC1. NIH ResearchFestival.
  27. Newman, T., Friedman, T.C., Mastorakos, G., Bouzas, E.A., Mullen, N.M., Horton, E. and Chrousos, G.P. (1994) Carbohydrate Metabolism, Bone Density and Ophthalmologic Findings in Endogenous Hypercortisolism. American Society for Clinical Investigation Abstract #A-EN-0053.
  28. Friedman, T.C. and Yanovski, J.A. (1994)Plasma Free Cortisol in Patients with Cushing Syndrome, Pseudo-Cushing Statesand Normal Volunteers. Endocrine Soc. 76:355.
  29. Yanovski, J., Yanovski, S,. Friedman, T., Harrington, L. and Chrousos, G. (1994) Differences in the Hypothalmic-Pituitary-Adrenal (HPA) Axis of Blacks and Whites. Endocrine Soc. 76:39.
  30. Mastorakos, G., Scopa, C.D., Vryonidou, A., Friedman, T.C., Phenekos, C., and Chrousos, G.P. (1994) Presence of Immunoreactive Corticotropin Releasing Hormone (CRH) in Normal and Polycystic Human Ovaries. Endocrine Soc. 76:1667.
  31. Friedman, T.C., Gordon, V.M., Leppla, S.H., Klimpel, K.R., Birch, N.P. and Loh, Y.P. (1994) In Vitro Processing of Anthrax Toxin Protective Antigen by Recombinant PC1(SPC3) and Bovine Intermediate Lobe Secretory Vesicle Membranes. The Gordon Research Conference on Hormonal and Neural Peptide Biosynthesis.
  32. Friedman, T.C., Yanovski, J.A., Morris, J., Alvarez, J.F., and Kalogeras, K.T. (1994) Arginine Vasopressin Concentrations in the Inferior Petrosal Sinuses of Normal Volunteers and Patients with Cushing Disease. First World Congress on Stress, Abstract #69.
  33. Garcia-Borreguero, D., Friedman, T., Neuhaus, I., Munson, P., Chrousos, G.P., and Kling, M. (1994) Pattern of Secretion of ACTH Pulses During REM Sleep in Healthy Adults. Preliminary Results. First World Congress on Stress, Abstract #74.
  34. Taymans, S.E., DeVries, A.C., Friedman, T.C., Jayasvasti, V., Carter, C.S., and Chrousos, G.P. (1994) HPA Axis Hormones in Monogamous Vs. Polygamous Voles. First World Congress on Stress, Abstract #256.
  35. Yao, P.D., Yanovski, J.A., Friedman, T.C., de la Paz, M., Bargas, L.R., Foroughi, A., Doppman, J.L., Kalogeras, K.T.(1994) The Role of Posterior Pituitary Hormones in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis in the Inferior Petrosal Sinuses of Normal Human Subjects. First World Congress on Stress, Abstract #284.
  36. Friedman, T.C., Cool, D.R., Jayasvasti, V., Louie, D., and Loh. Y.P. (1995) Processing of POMC in GH3 Cells: Insights from Antisense Experiments. Cedars-Sinai Research Institute-3rd Annual Retreat, Abstract #14.
  37. Friedman, T.C., Cool, D.R., Jayavasti, V., Louie, D., and Loh. Y.P. (1995) Processing of POMC in GH3 Cells: Insights from Antisense Experiments. Endocrine Soc. 77:OR13-2.
  38. Mastorakos, G., Bouzas, E.A., Silver, P.B., Sartani, G., Friedman, T.C., Chan, C-C., Caspi, R.C., and Chrousos, G.P.(1995) Immune Corticotropin Releasing Hormone (CRH) is Present in the Eyesof and Promotes Experimental Autoimmune Uveoretinitis (EAU) in Rodents. Endocrine Soc. 77:OR15-2.
  39. Mastorakos, G., Skopa, C.D., Kao, L.C., Vryonidou, A., Friedman, T.C., Kattis, D., Phenekos, C., Rabin, D., and Chrousos, G.P. (1995) Presence of Immunoreactive Corticotropin Releasing Hormone (CRH) in Human Endometrium. Endocrine Soc. 77:P1-105.
  40. Dorn, L.D., Friedman, T.C., Gold, P.W., and Chrousos, G.P. (1995) The Post Cure Longitudinal Course of Psychopathology in Cushing Syndrome.  Endocrine Soc. 77:P2-167.
  41. Yanovski, J.A., Friedman, T.C., Nieman, L.K., Doppman, J.L., Cutler, Jr., G.B., Chrousos, G.P., and Kalogeras, K.T. (1996) Arginine Vasopressin in the Inferior Petrosal Sinuses of Patients with Cushing Disease, Ectopic ACTH Syndrome and Adrenal Adenomas. Tenth InternationalCongress of Endocrinology P3-591.
  42. Nie, Y. and Friedman, T.C. (1998) Regulation of PC1 and PC2 by Morphine and Naltrexone: Implication in the Homeostatic Response to Opiate Addiction. Endocrine Soc. 80:P1-75.
  43. Li, Q.-L., Jude, M., and Friedman, T.C. (1998) Regulation of the Prohormone Convertase 1 (PC1) by JAK/STAT related cytokines. Endocrine Soc. 80:OR51-6.
  44. Friedman, T.C., Readhead, C.W., and Govan, III, H.L. (1998) Prohormone Convertase 4 (PC4) Isoforms in Testicular Cell Lines. Endocrine Soc. 80:P2-67.
  45. Yanovski, J.A.,Miller, K.D., Friedman, T.C., Jones, E., Chrousos, G.P., and Falloon, J. (1998) HPA-Axis Function in HIV+ Patients with Indinavir-Induced Lipodystrophy. Endocrine Soc. 80:P2-453.
  46. Shimon, I., Yan, X., Ren, S.G., Magoffin, D.A., Friedman, T.C., and Melmed, S. (1998) Long Leptin Receptor Isoformis Selectively Expressed in Human Fetal Pituitary and Pituitary AdenomasandSignals Fetal Pituitary Growth Hormone Secretion. Endocrine Soc. 80:P2-211.
  47. Garcia-Borreguero, D., Friedman, T.C., Chrousos, G.P., and Wehr, T.A. (1998) Withdrawal of glucocorticoids increases REM-sleep latency in patients with adrenal insufficiency. J. Sleep Res. 7: Supplement 2.
  48. Nie, Y., Nakashima, M., Perfetti, R., Jansen, E., Plagova, M., Pipeleers, D., and Friedman, T.C. (1999) Regulation of Pancreatic PC1 in Diabetic Rats. Endocrine Soc. 81:P2-231.
  49. Li, Q.-L., Brent, G., Wilber, J.F., Jansen, E., and Friedman, T.C. (1999) Interactions Between the Prohormone Convertase 2 (PC2) Promoter and the Thyroid Hormone Receptor. Endocrine Soc. 81:P2-662.
  50. Nie, Y., Nakashima, M., Perfetti, R., Jansen, E., Plagova, M., Pipeleers, D., and Friedman, T.C. (2000) Regulation of Pancreatic PC1 and PC2 Associated with Increased GLP-1 in Diabetic Rats. Endocrine Soc. 82:350.
  51. Friedman, T.C., Nakashima, M., Li, Q.-L., Nie, Y., Perfetti, R. and Friedman, T.C. (2000) Regulation of Pancreatic PC1 and PC2 Associated with Increased GLP-1 in Diabetic Rats. Endocrine Soc. 82:350.
  52. Ahmat, A.T., Brent, G.A., and Friedman, T.C., (2001) Treatment of Amiodarone-induced Hypothyroidism by Triiodothyronine. Endocrine Soc. 82:MTP350.
  53. Brubaker, P.L., Nakashima, M., Li, Q.-L., Nie, Y., Perfetti, R. and Friedman, T.C., (2000) Increased Pancreatic PC1 and PC2 are Associated with Increased GLP-1 in Diabetic Rats. Canadian Diabetes Assoc.
  54. Friedman, T.C., Nie, Y., Nakashima, M., Li, Q.-L., Chen, F., and Brubaker, P. (2001) Regulation of Pancreatic PC1 and PC2 Associated with Increased GLP-1 in Diabetic Rats and Pancreatic Cell Lines. J. Invest. Med. 49:61S.
  55. Echeverry, D.M. and Friedman, T.C. (2001) Glucocorticoid-Remedial Aldosteronism: Nuances and Clues to the Diagnosis. Endocrine Soc. 83:M58-2.
  56. Liu, Y.J., Nakagawa, Y. , Wang, Y., Toya, K. , Friedman, T.C., Li, R.S. and Ohzeki, T. (2001) Reduction of 11 -Hydroxysteroid Dehydrogenase Type 1 Messenger Ribonucleic Acid Expression in Livers of ob/ob Mice. Endocrine Soc. 83:P1-299.
  57. Friedman, T.C., Li, Q.-L., Shen, X., Lindberg, I. (2001) Prohormone Convertase 2 (PC2) Enzymatic Activity and its Regulation in Endocrine Cells. Endocrine Soc. 83:P3-361.
  58. Liu, Y.J., Lutfy, K., Steiner, D.F., Friedman, T.C., (2002) Nocioception, Tolerance and Dependence in PC2 Knockout Mice. Endocrine Soc. 84:P1-191.
  59. Shen , X., Li, Q.-L., Jansen, E., Brent, GA., Friedman, T.C. (2002) Interactions Between the Prohormone Convertase 1 (PC1) Promoter and Thyroid Hormone. Endocrine Soc. 84:P2-518.
  60. Wang, C., Kipnes, M., Matsumoto, A., Dobbs, A.S., Cunningham, G., Katznelson, L., Weber, T.J., Friedman, T.C., Snyder, P. (2002) Novel Testosterone Bioadhesive Buccal Tablet - Pharmacokinetics and Safety Evaluation. Endocrine Soc. 84:P2-645.
  61. *^ Lutfy, K., Liu, Y.J., Steiner, D.F., Furutu, M., Friedman, T.C., (2002) Nocioception, Tolerance and Dependence in PC2 Knockout Mice. 33rd International Narcotics Research Conference. S13.
  62. Friedman, T.C., Davoudi, S., Daigle, K., Barron, D.S., Lee, M.L., Poland, R.E. (2003) Renin-Aldosterone Axis and Orthostatic Hypotension in Patients with CFS. 6th International Conference on Chronic Fatigue Syndrome, Fibromyalgia and Related Illnesses. Physiology Abstracts.
  63. Friedman, T.C., Zuckerbraun, E., Storer, T., Berman, J., Magliano, L., Woodhouse, L., Bhasin, S. (2003) Muscle strength, physical and sexual function in women with hypopituitarism. 8th International Pituitary Congress. P71.
  64. Liu, Y., Nakagawa, Y., Wang, Y., Li, R., Ohzeki, T., Friedman, T.C. (2003) The Interaction of Leptin with 11?-Hydroxysteroid Dehydrogenase Type 1 in Hepatocytes May Mediate the Obesity Phenotype of Ob/Ob Mice. Endocrine Soc. 85: P1-444.
  65. Friedman, T.C., Zuckerbraun, E., Ghanaat, F., Daigle, K., Barron, D.S., Poland, R.E. (2003) High Prevalence of Renin-Aldosterone Axis Abnormalities in Patients with Chronic Fatigue Syndrome (CFS). Endocrine Soc. 85:P1-533.
  66. Sanchez, V.C., Goldstein, J., Stuart, R., Munzberg, H., Friedman, T.C., Liu, Y., Bjorbaek, C., Nillni, E.A. (2003) Regulation of the Hypothalamic Prohormone Convertases 1 and 2 Expression by Fasting and Leptin Endocrine Soc. 85:P3-113.
  67. Choi, H.H., Friedman, T.C. (2003) Mysterious Suprasellar Mass Causing Hypopituitarism. Endocrine Soc. 85:P3-648.

    *Oral presentation
    ^Travel award


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